Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

AIMS/HYPOTHESIS: Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpinning...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Diabetologia
Päätekijät: Lay, Abigail C., Hurcombe, Jenny A., Betin, Virginie M. S., Barrington, Fern, Rollason, Ruth, Ni, Lan, Gillam, Lawrence, Pearson, Grace M. E., Østergaard, Mette V., Hamidi, Hellyeh, Lennon, Rachel, Welsh, Gavin I., Coward, Richard J. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448913/
https://ncbi.nlm.nih.gov/pubmed/28852804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4394-0
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia