Evaluating CAR-T Cell Therapy in a Hypoxic 3-D Tumor Model

Despite its revolutionary success in hematological malignancies, chimeric antigen receptor (CAR) T cell therapy faces disappointing clinical results in solid tumors. The poor efficacy has been partially attributed to the lack of understanding in how CAR-T cells function in a solid tumor microenviron...

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Pubblicato in:Adv Healthc Mater
Autori principali: Ando, Yuta, Siegler, Elizabeth, Ta, Hoang P., Cinay, Gunce E., Zhou, Hao, Gorrell, Kimberly A., Au, Hannah, Jarvis, Bethany M., Wang, Pin, Shen, Keyue
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448565/
https://ncbi.nlm.nih.gov/pubmed/30734529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201900001
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