Preclinical characterization of SHR6390, a novel CDK 4/6 inhibitor, in vitro and in human tumor xenograft models

Inhibition of the cyclin‐dependent kinase (CDK) 4/6‐retinoblastoma (RB) pathway is an effective therapeutic strategy against cancer. Here, we performed a preclinical investigation of the antitumor activity of SHR6390, a novel CDK4/6 inhibitor. SHR6390 exhibited potent antiproliferative activity agai...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Long, Fei, He, Ye, Fu, Haoyu, Li, Yun, Bao, Xubin, Wang, Quanren, Wang, Yigang, Xie, Chengying, Lou, Liguang
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447953/
https://ncbi.nlm.nih.gov/pubmed/30724426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13957
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