Ca(2+)-dependent regulation of sodium channels Na(V)1.4 and Na(V)1.5 is controlled by the post-IQ motif

Skeletal muscle voltage-gated Na(+) channel (Na(V)1.4) activity is subject to calmodulin (CaM) mediated Ca(2+)-dependent inactivation; no such inactivation is observed in the cardiac Na(+) channel (Na(V)1.5). Taken together, the crystal structures of the Na(V)1.4 C-terminal domain relevant complexes...

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Publicat a:Nat Commun
Autors principals: Yoder, Jesse B., Ben-Johny, Manu, Farinelli, Federica, Srinivasan, Lakshmi, Shoemaker, Sophie R., Tomaselli, Gordon F., Gabelli, Sandra B., Amzel, L. Mario
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447637/
https://ncbi.nlm.nih.gov/pubmed/30944319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09570-7
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