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High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system
A cultivation strategy to increase the productivity of Modified Vaccinia Ankara (MVA) virus in high-cell density processes is presented. Based on an approach developed in shake flask cultures, this strategy was established in benchtop bioreactors, comprising the growth of suspension AGE1.CR.pIX cell...
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| Published in: | Appl Microbiol Biotechnol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Berlin Heidelberg
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447503/ https://ncbi.nlm.nih.gov/pubmed/30796494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-09694-2 |
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