Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode

Influenza viruses have been successfully propagated using a variety of animal cell lines in batch, fed-batch, and perfusion culture. For suspension cells, most studies reported on membrane-based cell retention devices typically leading to an accumulation of viruses in the bioreactor in perfusion mod...

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Detalhes bibliográficos
Main Authors: Juliana Coronel, Gwendal Gränicher, Volker Sandig, Thomas Noll, Yvonne Genzel, Udo Reichl
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
Colecção:Frontiers in Bioengineering and Biotechnology
Assuntos:
inclined settler
influenza vaccine
perfusion
suspension cell culture
continuous harvesting
Acesso em linha:https://www.frontiersin.org/article/10.3389/fbioe.2020.00672/full
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