Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents

Cocaine-induced vasoconstriction reduces blood flow, which can jeopardize neuronal function and in the prefrontal cortex (PFC) it may contribute to compulsive cocaine intake. Here we used integrated optical imaging in a rat self-administration and a mouse non-contingent model, to investigate whether...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Du, Congwu, Volkow, Nora D., You, Jiang, Park, Kicheon, Allen, Craig P., Koob, George F., Pan, Yingtian
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447479/
https://ncbi.nlm.nih.gov/pubmed/30283033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0261-8
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