Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

In atherosclerosis, macrophage accumulation is directly linked to the destabilization and rupture of plaque, causing acute atherothrombotic events. Circulating monocytes enter the plaque and differentiate into macrophages, where they are activated by CD4+ T-lymphocytes through CD40-CD40 ligand signa...

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Dades bibliogràfiques
Publicat a:Nat Biomed Eng
Autors principals: Lameijer, Marnix, Binderup, Tina, van Leent, Mandy M.T., Senders, Max L., Fay, Francois, Malkus, Joost, Sanchez-Gaytan, Brenda L., Teunissen, Abraham J. P., Karakatsanis, Nicolas, Robson, Philip, Zhou, Xianxiao, Ye, Yuxiang, Wojtkiewicz, Gregory, Tang, Jun, Seijkens, Tom T.P., Kroon, Jeffrey, Stroes, Erik S.G., Kjaer, Andreas, Ochando, Jordi, Reiner, Thomas, Pérez-Medina, Carlos, Calcagno, Claudia, Fischer, Edward A., Zhang, Bin, Temel, Ryan E., Swirski, Filip K., Nahrendorf, Matthias, Fayad, Zahi A., Lutgens, Esther, Mulder, Willem J.M., Duivenvoorden, Raphaël
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447057/
https://ncbi.nlm.nih.gov/pubmed/30936448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-018-0221-2
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