KAT8 selectively inhibits antiviral immunity by acetylating IRF3

The transcription factor interferon regulatory factor 3 (IRF3) is essential for virus infection–triggered induction of type I interferons (IFN-I) and innate immune responses. IRF3 activity is tightly regulated by conventional posttranslational modifications (PTMs) such as phosphorylation and ubiquit...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Huai, Wanwan, Liu, Xingguang, Wang, Chunmei, Zhang, Yunkai, Chen, Xi, Chen, Xiang, Xu, Sheng, Thomas, Tim, Li, Nan, Cao, Xuetao
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446880/
https://ncbi.nlm.nih.gov/pubmed/30842237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181773
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