The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3

Lysine methylation is an important posttranslational modification, implicated in various biological pathological conditions. The transcription factor interferon regulatory factor 3 (IRF3) is essential for antiviral innate immunity, yet the mechanism for methylation control of IRF3 activation remains...

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Vydáno v:J Exp Med
Hlavní autoři: Wang, Chunmei, Wang, Qinlan, Xu, Xiaoqing, Xie, Bin, Zhao, Yong, Li, Nan, Cao, Xuetao
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716042/
https://ncbi.nlm.nih.gov/pubmed/29101251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170856
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