The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3

Lysine methylation is an important posttranslational modification, implicated in various biological pathological conditions. The transcription factor interferon regulatory factor 3 (IRF3) is essential for antiviral innate immunity, yet the mechanism for methylation control of IRF3 activation remains...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Wang, Chunmei, Wang, Qinlan, Xu, Xiaoqing, Xie, Bin, Zhao, Yong, Li, Nan, Cao, Xuetao
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716042/
https://ncbi.nlm.nih.gov/pubmed/29101251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170856
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