Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells

Tcf1 and Lef1 have versatile functions in regulating T cell development and differentiation, but intrinsic requirements for these factors in regulatory T (T reg) cells remain to be unequivocally defined. Specific ablation of Tcf1 and Lef1 in T reg cells resulted in spontaneous multi-organ autoimmuni...

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Udgivet i:J Exp Med
Main Authors: Xing, Shaojun, Gai, Kexin, Li, Xiang, Shao, Peng, Zeng, Zhouhao, Zhao, Xudong, Zhao, Xin, Chen, Xia, Paradee, William J., Meyerholz, David K., Peng, Weiqun, Xue, Hai-Hui
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446865/
https://ncbi.nlm.nih.gov/pubmed/30837262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182010
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