MAP7 family proteins regulate kinesin-1 recruitment and activation

Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes. Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four mammalian MAP7 family members bind to kinesin-1. In HeLa cells, MAP7, MAP7D1, and MAP7D3 act redundantly to enable kinesin-1–d...

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Vydáno v:J Cell Biol
Hlavní autoři: Hooikaas, Peter Jan, Martin, Maud, Mühlethaler, Tobias, Kuijntjes, Gert-Jan, Peeters, Cathelijn A.E., Katrukha, Eugene A., Ferrari, Luca, Stucchi, Riccardo, Verhagen, Daan G.F., van Riel, Wilhelmina E., Grigoriev, Ilya, Altelaar, A.F. Maarten, Hoogenraad, Casper C., Rüdiger, Stefan G.D., Steinmetz, Michel O., Kapitein, Lukas C., Akhmanova, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446838/
https://ncbi.nlm.nih.gov/pubmed/30770434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201808065
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