Sulfur Dioxide Activates Cl(-)/HCO(3)(-) Exchanger via Sulphenylating AE2 to Reduce Intracellular pH in Vascular Smooth Muscle Cells

Sulfur dioxide (SO(2)) is a colorless and irritating gas. Recent studies indicate that SO(2) acts as the gas signal molecule and inhibits vascular smooth muscle cell (VSMC) proliferation. Cell proliferation depends on intracellular pH (pH(i)). Transmembrane cystein mutation of Na(+)- independent Cl(...

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Udgivet i:Front Pharmacol
Main Authors: Wang, Yi, Wang, Xiuli, Chen, Selena, Tian, Xiaoyu, Zhang, Lulu, Huang, Yaqian, Tang, Chaoshu, Du, Junbao, Jin, Hongfang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446831/
https://ncbi.nlm.nih.gov/pubmed/30971931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00313
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