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Multiple factors contribute to bimodal toxin gene expression in Clostridioides (Clostridium) difficile

Clostridioides (formerly Clostridium) difficile produces two major toxins, TcdA and TcdB, upon entry into stationary phase. Transcription of tcdA and tcdB requires the specialized sigma factor, σ(TcdR), which also directs RNA Polymerase to transcribe tcdR itself. We fused a gene for a red fluorescen...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Microbiol
Hauptverfasser: Ransom, Eric M., Kaus, Gabriela M., Tran, Phuong M., Ellermeier, Craig D., Weiss, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446242/
https://ncbi.nlm.nih.gov/pubmed/30125399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14107
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