Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma.

PURPOSE: Endoglin (ENG; CD105) is a co-receptor of the transforming growth factor-β (TGF-β) family that is highly expressed in proliferating endothelial cells. Often coopted by cancer cells, ENG can lead to neo-angiogenesis and vasculogenic mimicry in aggressive malignancies. It exists both as a tra...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Puerto-Camacho, Pilar, Amaral, Ana Teresa, Lamhamedi-Cherradi, Salah-Eddine, Menegaz, Brian A., Castillo-Ecija, Helena, Ordóñez, José Luis, Domínguez, Saioa, Jordan-Perez, Carmen, Diaz-Martin, Juan, Romero-Pérez, Laura, Lopez-Alvarez, Maria, Civantos-Jubera, Gema, Robles-Frías, María José, Biscuola, Michele, Ferrer, Cristina, Mora, Jaume, Cuglievan, Branko, Schadler, Keri, Seifert, Oliver, Kontermann, Roland, Pfizenmaier, Klaus, Simón, Laureano, Fabre, Myriam, Carcaboso, Ángel M., Ludwig, Joseph A., de Álava, Enrique
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445738/
https://ncbi.nlm.nih.gov/pubmed/30420447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0936
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