Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we investigated the function of BBK32 orthologues of the Lyme-associated Borrelia...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS Pathog
Hlavní autoři: Xie, Jialei, Zhi, Hui, Garrigues, Ryan J., Keightley, Andrew, Garcia, Brandon L., Skare, Jon T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445466/
https://ncbi.nlm.nih.gov/pubmed/30897158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007659
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky