Llwytho...

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we investigated the function of BBK32 orthologues of the Lyme-associated Borrelia...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Xie, Jialei, Zhi, Hui, Garrigues, Ryan J., Keightley, Andrew, Garcia, Brandon L., Skare, Jon T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445466/
https://ncbi.nlm.nih.gov/pubmed/30897158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007659
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