Design, synthesis and evaluation of (18)F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging

Carbonic anhydrase IX (CA-IX) is a marker for tumor hypoxia, and its expression is negatively correlated with patient survival. CA-IX represents a potential target for eliminating hypoxic cancers. We synthesized fluorinated cationic sulfonamide inhibitors 1–3 designed to target CA-IX. The binding af...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Zhang, Zhengxing, Lau, Joseph, Zhang, Chengcheng, Colpo, Nadine, Nocentini, Alessio, Supuran, Claudiu T., Bénard, François, Lin, Kuo-Shyan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445240/
https://ncbi.nlm.nih.gov/pubmed/28385087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1308928
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