3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Pustenko, Aleksandrs, Stepanovs, Dmitrijs, Žalubovskis, Raivis, Vullo, Daniela, Kazaks, Andris, Leitans, Janis, Tars, Kaspars, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445229/
https://ncbi.nlm.nih.gov/pubmed/28537099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1316720
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