Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

Sulphamate and sulphamide derivatives have been largely investigated as carbonic anhydrase inhibitors (CAIs) by means of different experimental techniques. However, the structural determinants responsible for their different binding mode to the enzyme active site were not clearly defined so far. In...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: De Simone, Giuseppina, Langella, Emma, Esposito, Davide, Supuran, Claudiu T., Monti, Simona Maria, Winum, Jean-Yves, Alterio, Vincenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445192/
https://ncbi.nlm.nih.gov/pubmed/28738704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1349764
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge