A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies

The treatment of B-cell malignancies by adoptive cell transfer (ACT) of anti-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a highly successful therapeutic modality in several clinical trials.(1–6) The anti-CD19 CAR-T cell production method used to support initial trials relied...

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Publicat a:Hum Gene Ther Methods
Autors principals: Lu, Tangying Lily, Pugach, Omar, Somerville, Robert, Rosenberg, Steven A., Kochenderfer, James N., Better, Marc, Feldman, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445175/
https://ncbi.nlm.nih.gov/pubmed/27897048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2016.120
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