A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts

BACKGROUND: The chitinase-like protein YKL-40 plays a major role in inhibiting the inflammasome. Deregulation of inflammasome activation is emerging as a key modulator of pathologic airway inflammation in patients with asthma. We determined whether cis-expression quantitative trait loci (eQTLs) of t...

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Pubblicato in:BMC Med Genet
Autori principali: Kanazawa, Jun, Kitazawa, Haruna, Masuko, Hironori, Yatagai, Yohei, Sakamoto, Tohru, Kaneko, Yoshiko, Iijima, Hiroaki, Naito, Takashi, Saito, Takefumi, Noguchi, Emiko, Konno, Satoshi, Nishimura, Masaharu, Hirota, Tomomitsu, Tamari, Mayumi, Hizawa, Nobuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444873/
https://ncbi.nlm.nih.gov/pubmed/30940096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-019-0786-y
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