Population pharmacokinetics of primaquine and the effect of hepatic and renal dysfunction: An exploratory approach

OBJECTIVES: We attempted to develop a population pharmacokinetic model for primaquine (PQ) and evaluate the effect of renal and hepatic dysfunction on PQ pharmacokinetics. MATERIALS AND METHODS: The data were collected from a prospective, nonrandomized clinical study in healthy volunteers and patien...

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Detalhes bibliográficos
Publicado no:Indian J Pharmacol
Main Authors: Sridharan, Kannan, Sannala, Chenna Keshava Reddy, Mallayasamy, Surulivelrajan, Chaturvedula, Ayyappa, Kadam, Prashant, Hase, Nivrutti, Shukla, Akash, Gogtay, Nithya, Thatte, Urmila
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer - Medknow 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444836/
https://ncbi.nlm.nih.gov/pubmed/31031463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/ijp.IJP_230_16
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