FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

BACKGROUND: Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (FNDC5) in cardiac inflammation and oxidative stress in obesity-induced cardiac h...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Geng, Zhi, Fan, Wen-Yong, Zhou, Bing, Ye, Chao, Tong, Ying, Zhou, Ye-Bo, Xiong, Xiao-Qing
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444535/
https://ncbi.nlm.nih.gov/pubmed/30940158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1857-8
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