Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice

Glucocorticoids are potent and widely used medicines but often cause metabolic side effects. A murine model of corticosterone treatment resulted in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycemia. We investigated how these adverse effe...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Sefton, Charlotte, Davies, Alison, Allen, Tiffany-Jayne, Wray, Jonathan R, Shoop, Rosemary, Adamson, Antony, Humphreys, Neil, Coll, Anthony P, White, Anne, Harno, Erika
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444294/
https://ncbi.nlm.nih.gov/pubmed/30794724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00018
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