Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion

Mutations within the Shank3 gene, which encodes a key postsynaptic density (PSD) protein at glutamatergic synapses, contribute to the genetic etiology of defined autism spectrum disorders (ASDs), including Phelan-McDermid syndrome (PMS) and intellectual disabilities (ID). Although there are a series...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Song, Tian-Jia, Lan, Xing-Yu, Wei, Meng-Ping, Zhai, Fu-Jun, Boeckers, Tobias M., Wang, Jia-Nan, Yuan, Shuo, Jin, Meng-Ying, Xie, Yu-Fei, Dang, Wan-Wen, Zhang, Chen, Schön, Michael, Song, Pei-Wen, Qiu, Mei-Hong, Song, Ya-Yue, Han, Song-Ping, Han, Ji-Sheng, Zhang, Rong
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444209/
https://ncbi.nlm.nih.gov/pubmed/30971895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00111
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