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3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition

Flavones are known as an inhibitor of tankyrase, a potential drug target of cancer. We here expedited the use of different computational approaches and presented a fast, easy, cost-effective and high throughput screening method to identify flavones analogs as potential tankyrase inhibitors. For this...

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Publicat a:Sci Rep
Autors principals: Alam, Sarfaraz, Khan, Feroz
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443786/
https://ncbi.nlm.nih.gov/pubmed/30932078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41984-7
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