Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways. Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint controls the fidelity of chromosome segregation during mitosis. Here, we show that insulin receptor substrate 1 and...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Choi, Eunhee, Kikuchi, Sotaro, Gao, Haishan, Brodzik, Karolina, Nassour, Ibrahim, Yopp, Adam, Singal, Amit G., Zhu, Hao, Yu, Hongtao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443781/
https://ncbi.nlm.nih.gov/pubmed/30931927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09318-3
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