Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associat...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Polo, Sara, Díaz, Andrés Felipe, Gallardo, Núria, Leánez, Sergi, Balboni, Gianfranco, Pol, Olga
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443715/
https://ncbi.nlm.nih.gov/pubmed/30971925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00283
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