In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance

BACKGROUND AND PURPOSE: δ-Opioid receptors (DOP receptors) could represent a novel target in the treatment of depressive disorders. To explore this new field of interest, the development of highly selective DOP receptor agonists is essential. UFP-512 [H-Dmt-Tic-NH-CH(CH(2)-COOH)-Bid], was recently s...

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Detalhes bibliográficos
Main Authors: Aguila, B, Coulbault, L, Boulouard, M, Lιveillι, F, Davis, A, Tσth, G, Borsodi, A, Balboni, G, Salvadori, S, Jauzac, P, Allouche, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189997/
https://ncbi.nlm.nih.gov/pubmed/17982482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707497
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