The Influence of Energy Depletion by Metformin or Hypocaloric Diet on Thyroid Iodine Uptake in Healthy Volunteers: a Randomized Trial

Sufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS). Activation of AMP-activated-protein-kinase (AMPK), leads to decreased NIS expression and thyroid iodine uptake in in vitro and animal models. Cli...

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Vydáno v:Sci Rep
Hlavní autoři: Sloot, Yvette J. E., Janssen, Marcel J. R., van Herwaarden, Antonius E., Peeters, Robin P., Netea-Maier, Romana T., Smit, Johannes W. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443645/
https://ncbi.nlm.nih.gov/pubmed/30932012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41997-2
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