mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines

CONCEPT: Redifferentiation of thyroid carcinoma cells has the potential to increase the efficacy of radioactive iodine therapy in treatment-refractory, nonmedullary thyroid carcinoma (TC), leading to an improved disease outcome. Mammalian target of rapamycin (mTOR) is a key regulator of cell fate af...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Plantinga, Theo S., Heinhuis, Bas, Gerrits, Danny, Netea, Mihai G., Joosten, Leo A. B., Hermus, Ad R. M. M., Oyen, Wim J. G., Schweppe, Rebecca E., Haugen, Bryan R., Boerman, Otto C., Smit, Johannes W. A., Netea-Maier, Romana T.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393487/
https://ncbi.nlm.nih.gov/pubmed/24712572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1171
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