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Light-induced generation and toxicity of docosahexaenoate- derived oxidation products in retinal pigmented epithelial cells

Oxidative cleavage of docosahexaenoate (DHA) in retinal pigmented epithelial (RPE) cells produces 4-hydroxy-7- oxohept-5-enoic acid (HOHA) esters of 2-lysophosphatidylcholine (PC). HOHA-PC spontaneously releases a membrane- permeant HOHA lactone that modifies primary amino groups of proteins and eth...

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Bibliografiske detaljer
Udgivet i:Exp Eye Res
Main Authors: Cheng, Yu-Shiuan, Linetsky, Mikhail, Gu, Xilin, Ayyash, Naji, Gardella, Anthony, Salomon, Robert G.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443467/
https://ncbi.nlm.nih.gov/pubmed/30296412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.09.012
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