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Light-induced generation and toxicity of docosahexaenoate- derived oxidation products in retinal pigmented epithelial cells
Oxidative cleavage of docosahexaenoate (DHA) in retinal pigmented epithelial (RPE) cells produces 4-hydroxy-7- oxohept-5-enoic acid (HOHA) esters of 2-lysophosphatidylcholine (PC). HOHA-PC spontaneously releases a membrane- permeant HOHA lactone that modifies primary amino groups of proteins and eth...
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| Yayımlandı: | Exp Eye Res |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443467/ https://ncbi.nlm.nih.gov/pubmed/30296412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.09.012 |
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