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Macrophage-dependent impairment of α(2)-adrenergic autoreceptor inhibition of Ca(2+) channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats
DOCA-salt and obesity-related hypertension are associated with inflammation and sympathetic nervous system hyperactivity. Prejunctional α(2)-adrenergic receptors (α(2)ARs) provide negative feedback to norepinephrine release from sympathetic nerves through inhibition of N-type Ca(2+) channels. Increa...
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| Udgivet i: | Am J Physiol Heart Circ Physiol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443059/ https://ncbi.nlm.nih.gov/pubmed/29351460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00536.2017 |
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