Macrophage depletion lowers blood pressure and restores sympathetic nerve α(2)-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats

We tested the hypothesis that vascular macrophage infiltration and O(2)(−) release impairs sympathetic nerve α(2)-adrenergic autoreceptor (α(2)AR) function in mesenteric arteries (MAs) of DOCA-salt hypertensive rats. Male rats were uninephrectomized or sham operated (sham). DOCA pellets were implant...

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Publicado en:Am J Physiol Heart Circ Physiol
Autores principales: Thang, Loc V., Demel, Stacie L., Crawford, Robert, Kaminski, Norbert E., Swain, Greg M., Van Rooijen, Nico, Galligan, James J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
Materias:
Cardiovascular Neurohormonal Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666925/
https://ncbi.nlm.nih.gov/pubmed/26320034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00283.2015
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