CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia

The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impact of IMGN632, a conjugate of CD123-binding antibo...

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Vydáno v:Haematologica
Hlavní autoři: Angelova, Evgeniya, Audette, Charlene, Kovtun, Yelena, Daver, Naval, Wang, Sa A., Pierce, Sherry, Konoplev, Sergej N., Khogeer, Haitham, Jorgensen, Jeffrey L., Konopleva, Marina, Zweidler-McKay, Patrick A., Medeiros, L. Jeffrey, Kantarjian, Hagop M., Jabbour, Elias J., Khoury, Joseph D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442980/
https://ncbi.nlm.nih.gov/pubmed/30361418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.205252
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