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Secondary mutations as mediators of resistance to targeted therapy in leukemia
The advent of small molecule-based targeted therapy has improved the treatment of both acute and chronic leukemias. Resistance to small molecule inhibitors has emerged as a common theme. The most frequent mode of acquired resistance is the acquisition of point mutations in the kinase domain. FLT3 in...
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| Publicado no: | Blood |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440880/ https://ncbi.nlm.nih.gov/pubmed/25795921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-605808 |
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