Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

BACKGROUND: Cancer-associated fibroblasts (CAFs) are the predominant residents in the breast tumor microenvironment. In our work, we found activation of DNA damage-independent ATM (oxidized ATM), enhanced glycolysis and aberrant metabolism-associated gene expressions in breast CAFs. Nevertheless, wh...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Sun, Kexin, Tang, Shifu, Hou, Yixuan, Xi, Lei, Chen, Yanlin, Yin, Jiali, Peng, Meixi, Zhao, Maojia, Cui, Xiaojiang, Liu, Manran
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442874/
https://ncbi.nlm.nih.gov/pubmed/30799198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.025
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