Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is missing. Here, we generated chromatin maps and transcriptomes from four tissues and one cell type from young, middle-aged, and old mice—yield...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Benayoun, Bérénice A., Pollina, Elizabeth A., Singh, Param Priya, Mahmoudi, Salah, Harel, Itamar, Casey, Kerriann M., Dulken, Ben W., Kundaje, Anshul, Brunet, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442391/
https://ncbi.nlm.nih.gov/pubmed/30858345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.240093.118
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