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Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates

DNA ligases are the sine qua non of genome integrity and essential for DNA replication and repair in all organisms. DNA ligases join 3′-OH and 5′-PO(4) ends via a series of three nucleotidyl transfer steps. In step 1, ligase reacts with ATP or NAD(+) to form a covalent ligase-(lysyl-Nζ)–AMP intermed...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Unciuleac, Mihaela-Carmen, Goldgur, Yehuda, Shuman, Stewart
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442053/
https://ncbi.nlm.nih.gov/pubmed/30718283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007445
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