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Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates
DNA ligases are the sine qua non of genome integrity and essential for DNA replication and repair in all organisms. DNA ligases join 3′-OH and 5′-PO(4) ends via a series of three nucleotidyl transfer steps. In step 1, ligase reacts with ATP or NAD(+) to form a covalent ligase-(lysyl-Nζ)–AMP intermed...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442053/ https://ncbi.nlm.nih.gov/pubmed/30718283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007445 |
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