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Immunohistochemistry for Histone H3G34W and H3K36M Is Highly Specific for Giant Cell Tumor of Bone and Chondroblastoma, Respectively, in FNA and Core Needle Biopsy

BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all cho...

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Detalhes bibliográficos
Publicado no:Cancer Cytopathol
Main Authors: Schaefer, Inga-Marie, Fletcher, Jonathan A., Petur Nielsen, G., Shih, Angela R., Ferrone, Marco L., Hornick, Jason L., Qian, Xiaohua
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441393/
https://ncbi.nlm.nih.gov/pubmed/29757500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncy.22000
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