Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Genome-wide association studies (GWAS) have identified genetic variants at 34 loci contributing to age-related macular degeneration (AMD)(1–3). We generated transcriptional profiles of postmortem retina from 453 controls and cases at distinct stages of AMD and integrated retinal transcriptomes, cove...

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Published in:Nat Genet
Main Authors: Ratnapriya, Rinki, Sosina, Olukayode A., Starostik, Margaret R., Kwicklis, Madeline, Kapphahn, Rebecca J., Fritsche, Lars G., Walton, Ashley, Arvanitis, Marios, Gieser, Linn, Pietraszkiewicz, Alexandra, Montezuma, Sandra R., Chew, Emily Y., Battle, Alexis, Abecasis, Gonçalo R., Ferrington, Deborah A., Chatterjee, Nilanjan, Swaroop, Anand
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441365/
https://ncbi.nlm.nih.gov/pubmed/30742112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0351-9
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