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Differential stability of variant OPN1LW gene transcripts in myopic patients

PURPOSE: In Bornholm eye disease, a defect in the splicing of transcripts from a variant OPN1LW opsin gene leads to a depletion in spliced transcript levels and, consequently, a reduction in photopigment in photoreceptors expressing the variant gene. METHODS: Myopic and age-matched control subjects...

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Udgivet i:Mol Vis
Main Authors: Mountford, Jessica K., Davies, Wayne I. L., Griffiths, Lyn R., Yazar, Seyhan, Mackey, David A., Hunt, David M.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441357/
https://ncbi.nlm.nih.gov/pubmed/30996587
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