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The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance
BACKGROUND: Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that genetic or pharmacological inhibition of the NHEJ pathway could rescue the FA phen...
Gespeichert in:
| Veröffentlicht in: | Stem Cell Res Ther |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6441194/ https://ncbi.nlm.nih.gov/pubmed/30925933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1206-0 |
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