The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance

BACKGROUND: Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that genetic or pharmacological inhibition of the NHEJ pathway could rescue the FA phen...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Nie, Yan, Li, Yibo, Li, Xiaoli, Wilson, Andrew F., Pang, Qishen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441194/
https://ncbi.nlm.nih.gov/pubmed/30925933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1206-0
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