Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries: A Cohort and Nested Case–Control Study Using Automated Health Data Sources

BACKGROUND: Agomelatine is a melatonin receptor agonist and serotonin 5-HT(2C) receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. Hepatotoxic reactions have been repo...

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Publicado no:CNS Drugs
Main Authors: Pladevall-Vila, Manel, Pottegård, Anton, Schink, Tania, Reutfors, Johan, Morros, Rosa, Poblador-Plou, Beatriz, Timmer, Antje, Forns, Joan, Hellfritzsch, Maja, Reinders, Tammo, Hägg, David, Giner-Soriano, Maria, Prados-Torres, Alexandra, Cainzos-Achirica, Miguel, Hallas, Jesper, Brandt, Lena, Cortés, Jordi, Aguado, Jaume, Perlemuter, Gabriel, Falissard, Bruno, Castellsagué, Jordi, Jacquot, Emmanuelle, Deltour, Nicolas, Perez-Gutthann, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441103/
https://ncbi.nlm.nih.gov/pubmed/30830574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40263-019-00611-9
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