Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid

Staphylococcus aureus pneumonia is associated with high mortality irrespective of antibiotic susceptibility. Both MRSA and MSSA strains produce powerful cytotoxins: alpha-hemolysin(Hla) and up to five leukocidins – LukSF-PV, HlgAB, HlgCB, LukED and LukGH (LukAB) – to evade host innate defense mechan...

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Publicado no:Sci Rep
Main Authors: Stulik, Lukas, Rouha, Harald, Labrousse, Delphine, Visram, Zehra Claire, Badarau, Adriana, Maierhofer, Barbara, Groß, Karin, Weber, Susanne, Kramarić, Miroslava Dominis, Glojnarić, Ines, Nagy, Gábor, Croisier, Delphine, Nagy, Eszter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441091/
https://ncbi.nlm.nih.gov/pubmed/30926865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41826-6
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