Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating

Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection. Engineering Ngb to observe structural and dynamic alterations associated with perturbation in ligand binding might reveal important structural...

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Pubblicato in:Sci Rep
Autori principali: Exertier, Cécile, Milazzo, Lisa, Freda, Ida, Montemiglio, Linda Celeste, Scaglione, Antonella, Cerutti, Gabriele, Parisi, Giacomo, Anselmi, Massimiliano, Smulevich, Giulietta, Savino, Carmelinda, Vallone, Beatrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441039/
https://ncbi.nlm.nih.gov/pubmed/30926858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41780-3
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