Specialized dendritic cells induce tumor-promoting IL-10(+)IL-17(+) FoxP3(neg) regulatory CD4(+) T cells in pancreatic carcinoma

The drivers and the specification of CD4(+) T cell differentiation in the tumor microenvironment and their contributions to tumor immunity or tolerance are incompletely understood. Using models of pancreatic ductal adenocarcinoma (PDA), we show that a distinct subset of tumor-infiltrating dendritic...

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Udgivet i:Nat Commun
Main Authors: Barilla, Rocky M., Diskin, Brian, Caso, Raul Caso, Lee, Ki Buom, Mohan, Navyatha, Buttar, Chandan, Adam, Salma, Sekendiz, Zennur, Wang, Junjie, Salas, Ruben D., Cassini, Marcelo F., Karlen, Jason, Sundberg, Belen, Akbar, Hashem, Levchenko, Dmitry, Gakhal, Inderdeep, Gutierrez, Johana, Wang, Wei, Hundeyin, Mautin, Torres-Hernandez, Alejandro, Leinwand, Joshua, Kurz, Emma, Rossi, Juan A. Kochen, Mishra, Ankita, Liria, Miguel, Sanchez, Gustavo, Panta, Jyoti, Loke, P’ng, Aykut, Berk, Miller, George
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441038/
https://ncbi.nlm.nih.gov/pubmed/30926808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09416-2
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