Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells

CONTEXT: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans. OBJECTIVE: Determine GDF9 and BMP15 effects on FSH stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypo...

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Pubblicato in:J Clin Endocrinol Metab
Autori principali: Hobeika, Elie, Armouti, Marah, Kala, Hamsini, Fierro, Michele A, Winston, Nicola J, Scoccia, Bert, Zamah, Alberuni M, Stocco, Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2018
Soggetti:
Clinical Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441017/
https://ncbi.nlm.nih.gov/pubmed/30541132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-01705
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